Curculigo orchioides gaertn.

Ethnobotanical Studies

Studies

Curculigoside Regulates Apoptosis and Oxidative Stress Against Spinal Cord Injury by Modulating the Nrf-2/NQO-1 Signaling Pathway In Vitro and In Vivo.

Summary

Curculigoside (CUR) from Curculigo orchioides reduces apoptosis and oxidative stress in spinal cord injury, promoting tissue recovery and functional improvement through Nrf2/NQO1 signaling pathway. CUR shows promise for SCI treatment development.

Immunology
Hou Y et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-024-04409-9
PubMed:
39230866

Unraveling the Mechanism of Curculiginis Rhizoma in Suppressing Cisplatin Resistance in Non-Small Cell Lung Cancer: An Experimental Study.

Summary

Study investigates Curculiginis Rhizoma (CR) mixed with cisplatin to combat chemoresistance in NSCLC. Results show potential to enhance drug sensitivity by targeting ABC transporters. Crucial for improving chemotherapy outcomes in lung cancer.

Cancer
Huang X et al (2024).
Onco Targets Ther.
DOI:
10.2147/OTT.S448636
PubMed:
38895133

Orcinol gentiobioside inhibits RANKL-induced osteoclastogenesis by promoting apoptosis and suppressing autophagy via the JNK1 signaling.

Lian C et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118060
PubMed:
38521429

Network pharmacology and experimental validation methods to reveal the active compounds and hub targets of Curculigo orchioides Gaertn in rheumatoid arthritis.

Arthritis
Liu X et al (2023).
J Orthop Surg Res.
DOI:
10.1186/s13018-023-04352-w
PubMed:
37957674

Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier.

Summary

Curculigoside (CUR) has anti-inflammatory effects and helps maintain intestinal barrier function. It activates Nrf2 via Keap1/Nrf2 interaction, reducing oxidative stress and promoting autophagy. CUR can effectively treat colitis and may be used in UC therapy.

Gastroenterology
Li F et al (2023).
Int J Mol Med.
DOI:
10.3892/ijmm.2023.5310
PubMed:
37772380

Production of the antidepressant orcinol glucoside in Yarrowia lipolytica with yields over 6,400-fold higher than plant extraction.

Summary

Researchers used a screening pipeline to identify the genes responsible for biosynthesis of the antidepressant compound orcinal glucoside in a Chinese herb. They then improved production of the compound 100-fold by optimizing fermentation in Y. lipolytica. The final yield was 6,400 times higher than from the natural root source. This approach can be used to identify genes for other natural products and improve their production.

Neuroscience
Chen B et al (2023).
PLoS Biol.
DOI:
10.1371/journal.pbio.3002131
PubMed:
37279234

Protective Effect of Curculigo orchioides Gaertn. Extract on Heat Stress-Induced Spermatogenesis Complications in Murine Model.

Bui-Le TN et al (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45040212
PubMed:
37185736

Decipher the pharmacological mechanisms of raw and wine-processed Curculigo orchioides Gaertn. on bone destruction in rheumatoid arthritis rats using metabolomics.

Arthritis
Liu X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116395
PubMed:
36958673

Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway.

ArthritisImmunology
Gong W et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/5410377
PubMed:
35585885

Characterization of the complete chloroplast genome of medical plant Curculigo orchioides Gaertn. (Amaryllidaceae).

Genetics
Deng G et al (2021).
Mitochondrial DNA B Resour.
DOI:
10.1080/23802359.2020.1863875
PubMed:
33659650

Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis.

Review Arthritis
He J et al (2019).
Front Pharmacol.
DOI:
10.3389/fphar.2019.01344
PubMed:
31824310

Curculigo orchioides: the black gold with numerous health benefits.

Review
Chauhan NS et al (2010).
Zhong Xi Yi Jie He Xue Bao.
PubMed:
20619136

Evaluation of estrogenic activity of alcoholic extract of rhizomes of Curculigo orchioides.

Endocrinology
Vijayanarayana K et al (2007).
J Ethnopharmacol.
PubMed:
17900835